Figure 7: Predicting target projections for MET-types.

a, Predicted probabilities of projecting to cortical targets for L4/L5 IT neurons. Probabilities are predicted at different VISp locations (left) and for different transcriptomic-correlated dendritic PC values (right). Example neurons (right, above) were chosen at low, medium, and high values of the dendritic PC range for projection probability calculations. b, Predicted probabilities of projecting to cortical and subcortical targets for L5 ET-3 Stac neurons. The effects of VISp location and dendritic PC are shown as in (a). c, Summary of the effects of location and dendritic PC variation by MET-type. Probability ranges for major structures (cortex, striatum, thalamus, midbrain, and hindbrain) were calculated by averaging the lowest and highest predictions across the regions belonging to the structure, either by varying location (second column) or dendritic PC (third column). The rightmost column summarizes the morphological features that vary along the relevant dendritic, the genes inferred to vary by the corresponding Tx PC, and the distributions of dendritic PC values by MET-type.