Figure 1. AF2 predicts fold switching with modest success.

(a) Numbers of successful fold-switch predictions for each AF2 method compared with coevolutionary information found for both folds (ACE) and the total number of possible successes (dotted red line). All_AF2 combines all unique successful predictions from all AF2-based methods: >282,000 predictions. (b). Fraction of predicted structures that match experimentally determined conformations for all methods. Fold1 is the conformation most frequently sampled by AF2.3.1, Fold2 is the less frequently sampled (or unsampled) conformation. Conformations designated as Other are inconsistent with both experimentally determined structures.