Table 1.
Demographics and plasma biomarker concentrations
| Cognitively Unimpaired, N = 66 | MCI, N = 130 | Dementia, N = 94 | P value | |
|---|---|---|---|---|
| Age | 57 (12) | 71 (9) | 73 (8) | < 0.001 |
| Sex (Female) | 46 (70%) | 77 (59%) | 57 (61 %) | 0.3 |
| MMSE | 29.1 (0.9) | 25.4 (3.2) | 21.5 (4.2) | < 0.001 |
| APOE ε4 | 15 (23%) | 32 (25%) | 36 (38%) | 0.042 |
| Plasma pTau217 (pg/mL) | 0.15 (0.14) | 0.34 (0.31) | 0.59 (0.47) | < 0.001 |
| Plasma pTau181 (pg/mL) | 1.84 (0.61) | 2.54 (0.94) | 3.45 (1.54) | < 0.001 |
| Plasma Aβ1–42 (pg/mL) | 25.0 (3.6) | 23.9 (5.2) | 25.0 (6.0) | 0.028 |
| Plasma Aβ1–40 (pg/mL) | 295 (44) | 312 (55) | 335 (72) | < 0.001 |
| Plasma Aβ1–42/Aβ1-40 | 0.085 (0.008) | 0.077 (0.009) | 0.075 (0.008) | < 0.001 |
| A | < 0.001 | |||
| A+ | 5 (7.6%) | 66 (51 %) | 69 (73%) | |
| AT | < 0.001 | |||
| A-T- | 61 (92%) | 64 (49%) | 25 (27%) | |
| A + T- | 2 (3.0%) | 17 (13%) | 12 (13%) | |
| A + T+ | 3 (4.5%) | 49 (38%) | 57 (61 %) | |
| Etiology | < 0.001 | |||
| CU | 56 (85%) | 0 (0%) | 0 (0%) | |
| AD | 4 (6.1%) | 43 (33%) | 50 (53%) | |
| OtherNotDeg | 1 (1.5%) | 37 (28%) | 11 (12%) | |
| OtherDem | 3 (4.5%) | 18 (14%) | 20 (21 %) | |
| Uncertain | 2 (3.0%) | 32 (25%) | 13 (14%) | |
| VRF | 39 (60%) | 102 (82%) | 75 (85%) | < 0.001 |
| HBP | 24 (37%) | 71 (57%) | 49 (56%) | 0.021 |
| DM | 11 (17%) | 28 (23%) | 20 (23%) | 0.6 |
| DLP | 21 (32%) | 64 (52%) | 55 (63%) | 0.001 |
| eGFR (mL/min/1.73m3) | < 0.001 | |||
| >90 | 36 (64%) | 29 (23%) | 13 (14%) | |
| 60–90 | 18 (32%) | 91 (71 %) | 68 (72%) | |
| <60 | 2 (3.6%) | 8 (6.3%) | 13 (14%) |
Mean (SD); n (%)
Kruskal-Wallis rank sum test; Pearson's Chi-squared test; Fisher's exact test
Unless otherwise specified, values are presented as mean (SD).
CU, Cognitively Unimpaired. MCI, Mild cognitive impairment. AD, Alzheimer disease. OtherNotDeg, other not degenerative. OtherDem, Other diseases. VRF, one or more vascular risk factors. HBP, high blood pressure. DM, diabetes mellitus. DLP, dyslipidemia. eGFR, estimated glomerular filtration rate.