Extended Data Table 3.

Spearman correlations between p-tau biomarkers and with CSF and autopsy measures of amyloid and tau pathologies.

UCSD-Neuropathology cohort*
Biomarker	p-tau181	p-tau212	p-tau217	p-tau231	CSF Aβ42/40	CSF T-tau	Braak	CERAD
p-tau181	x	0.98	0.95	0.98	−0.71	0.90	0.58	0.63
p-tau212	0.98	x	0.95	0.97	−0.68	0.88	0.67	0.67
p-tau217	0.95	0.95	X	0.94	−0.69	0.86	0.59	0.65
p-tau231	0.88	0.87	0.94	x	−0.74	0.89	0.59	0.62
CSF Aβ42/40	−0.71	−0.68	−0.69	−0.74	x	−0.58	0.47	−0.48
CSF T-tau	0.90	0.88	0.86	0.89	−0.58	x	0.47	0.50
Braak	0.58	0.67	0.59	0.59	−0.47	0.47	x	0.69
CERAD	0.63	0.67	0.65	0.62	−0.48	0.50	0.69	x
Thal	0.58	0.61	0.60	0.57	−0,52	0.45	0.61	0.64

Polish cohort*
Biomarker	p-tau212 CSF	p-tau212 Plasma	MMSE	CSF-Aβ42/Aβ40	CSF T-tau	CSF p-tau
p-tau212 CSF	x	0.53	−0.42	−0.41	0.75	0.79
p-tau212 Plasma	0.53	x	−0.49	−0.3	0.48	0.37
MMSE	−0.42	−0.49	x	0.27	−0.41	−0.31
CSF-Aβ42/Aβ40	−0.41	−0.3	0.27	x	−0.61	−0.53

Gothenburg cohort*
Biomarker	p-tau181	p-tau212	p-tau231	CSF Aβ42	CSF T-tau	CSF p-tau
p-tau181	x	0.76	0.88	−0.58	0.67	0.60
p-tau212	0.76	x	0.87	−0.71	0.79	0.68
p-tau231	0.88	0.87	x	−0.67	0.66	0.60
CSF Aβ42	−0.58	−0.71	−0.67	x	−0.66	−0.68
CSF T-tau	0.67	0.79	0.66	−0.66	x	0.92
CSF p-tau	0.60	0.68	0.60	−0.68	0.92	x

BLSA-Neuropathology cohort*
Biomarker	p-tau181	p-tau212	p-tau231	CERAD	Braak
p-tau181	x	0.48	0.72	0.25	0.34
p-tau212	0.48	x	0.65	0.41	0.45
p-tau231	0.72	0.65	x	0.38	0.58
CERAD	0.25	0.41	0.38	x	0.66
Braak	0.34	0.45	0.58	0.66	x

^*All correlations were statistically significant (P<0.05).