Extended Data Table 4.

Demographic characteristics of the Gothenburg cohort

	Aβ− controls	Aβ+ AD
Sample size	14	16
Age, y	68.43 ± 9.835	76.63 ± 5.512*
Sex, F, n (%)	5/14 (35.7%)	9/16 (56.3%)
CSF Aβ42, pg/ml	1110 (672.8–1168)	457 (420.3–515)*
CSF total-tau, pg/ml	297 (175.8–354)	635 (496.5–999.3)*
CSF p-tau181 (Innotest), pg/ml	48 (32.5–57.3)	84 (71.8–100.5)*
Plasma p-tau212, pg/ml	1.0 (0.5 – 1.7	3.8 (2.6–6.8)*
Plasma p-tau231, pg/ml	4.9 (4.4 – 6.6)	11.22 (9.1–16.1)*
Plasma p-tau181, pg/ml	4.488 (3.7 – 6.7)	8.377 (7.2–12.4)*