Extended Data Table 5.

Demographic characteristics of the Polish cohort

	Aβ− controls	Aβ+ AD
Sample size	21	74
Age, y	63.82 ± 7.72	69.86 ± 8.508*
Sex, F, n (%)	11/21 (52%)	52/74 (70%)
MMSE	25 (21–28.3)	18 (15–23.3)*
CSF Aβ40	16706 (12167–18040)	4965 (12693–19470)*
CSF Aβ42, pg/ml	1030 (833.5–1174)	233 (389.5–570.8)*
CSF Aβ42/Aβ40 ratio	0.0645 (0.06–0.078)	0.033 (0.028–0.39)*
CSF total-tau, pg/ml	234 (2002.5–263.5)	565.5 (450–775.3)*
CSF p-tau181 (Innotest), pg/ml	46 (39–48.5)	95 (74.5–106.5)*
CSF p-tau212 (Simoa), pg/ml	38.55 (20.9–75.8)	384.5 (289.7–587.5)*
Plasma p-tau212, pg/ml	0.86 (0.42–2.2)	3.44 (2.1–5.6)*