Extended Data Table 6.
Demographic characteristics of the BLSA-Neuropathology cohort
| Controls | Asymptomatic | AD | |
|---|---|---|---|
| Sample size | 12 | 15 | 20 |
| Age, y | 76.40 ± 15.47 | 84.50 ± 8.507 | 82.71 ± 9.873 |
| Plasma – death interval | 4.450 ± 2.767 | 2.871 ± 2.295 | 5.022 ± 3.464 |
| Sex, F, n (%) | 2/12 (16.7%) | 5/15 (33.3%) | 11/20 (55%) |
| Neuritic Plaques: Low/None | 12/12 (100%) | 0/15 (0%) | 0/20 (0%) |
| Neuritic Plaques: Moderate | 0/12 (0%) | 3/15 (20%) | 4/20 (25%) |
| Neuritic Plaques: High | 0/12 (0%) | 12/15 (80%) | 16/20 (75%) |
| BRAAK 0-II | 4/12 (33.3%) | 1/15 (6.7%) | 0/20 (0%) |
| BRAAK III-IV | 8/12 (66.7%) | 13/15 (86.7%) | 6/20 (30%) |
| BRAAK V-VI | 0/12 (0%) | 1/15 (6.7%) | 14/20 (70%) |
| Plasma p-tau181, pg/ml | 7.7 (5.1 – 10.7)c | 6.84 (4.3–13.8) | 14.2 (9.4–18.4)a |
| Plasma p-tau231, pg/ml | 10.8 (8.7–18.4)c | 10.23 (8.1–19.2) | 18.75 (11.8–23.9)a |
| Plasma p-tau212 (Simoa), pg/ml | 1.2 (0.7–1.5)c | 1.012 (0.8–2.1)c | 4.022 (2.2–4.9)a,b |
a
– Different from Controls
b
– Different from ASYMAD
c
– Different from AD