Extended Data Table 7.
Demographic characteristics of the UCSD-Neuropathology cohort
| Low Pathology | ADNC | Other Pathologies | ADNC + other | |
|---|---|---|---|---|
| Sample Size | 8 | 21 | 19 | 19 |
| Age at Death | 81.6 ± 6.5 | 80.2 ± 9 | 77.7 ± 6.9 | 78.6 ± 8.5 |
| CSF - Death interval | 4.3 ± 2.1 | 4.6 ± 2.4 | 3.8 ± 1.7 | 4.8 ± 2.3 |
| Sex F, n, % | 4 (50%) | 10 (48%) | 8 (42%) | 7 (37%) |
| Education years | 12.8 ± 5.5 | 15.4 ± 4.3 | 17 ± 2.7 | 14.5 ± 2.8 |
| Neuritic Plaques: Low/None | 5 (62%) | 0 (0%) | 10 (53%) | 0 (0%) |
| Neuritic Plaques: Moderate | 2 (25%) | 6 (29%) | 8 (42%) | 7 (37%) |
| Neuritic Plaques: High | 1 (12%) | 15 (71%) | 1 (5%) | 12 (63%) |
| Braak 0-II | 4 (50%) | 0 (0%) | 9 (47%) | 0 (0%) |
| Braak III-IV | 4 (50%) | 0 (0%) | 9 (47%) | 0 (0%) |
| Braak V-VI | 0 (0%) | 21 (100%) | 0 (0%) | 19 (100%) |
| LBD: Brainstem | 0 (0%) | 0 (0%) | 1 (5%) | 0 (0%) |
| LBD: Limbic | 0 (0%) | 0 (0%) | 1 (5%) | 2 (11%) |
| LBD: Neocortical | 0 (0%) | 0 (0%) | 9 (47%) | 13 (68%) |
| Hippocampal Sclerosis | 0 (0%) | 0 (0%) | 1 (5%) | 5 (26%) |
| FTLD | 0 (0%) | 0 (0%) | 8 (42%) | 0 (0%) |
| Other Pathology | 0 (0%) | 0 (0%) | 0 (0%) | 2 (11%) |
| CSF p-tau181 | 242.5 (178.3–480.3)b | 906.5 (515.5–1012)a,c | 316.7 (168.8–502.9)b,d | 857.4 (547.8–2374)c |
| CSF p-tau231 | 373.7 (302.4–742.6)b | 1332 (753.7–1883)a,c | 469.9 (256.7–695.1)b,d | 1644 (702.5–2165)c |
| CSF p-tau212 | 62.4 (46.8–169.2)b,d | 444.6 (227.3–663.2)a,c | 102.8 (40.8–169.0)b,d | 441.2 (217–872.2)a,c |
| CSF p-tau217 | 2.2 (0.8–3.0)b | 11.35 (8.7–18.3)a,c | 3.97 (1.8–8.4)b,d | 11.35 (6.2–18.8)c |
a
– Statistically different from Low pathology
b
– Statistically different from ADNC
c
– Statistically different from Other Pathology
d
– Statistically different from ADNC + other pathology