Table 3:
Top-ranked alleles in the meta-analyses and corresponding results in the US prospective and CHGE cohorts.
| Allele | Meta-analysis | US Prospective Cohortb | CHGE Cohortb | ||||
|---|---|---|---|---|---|---|---|
| Meta-analysis number | OR [95% CI]a | p value | OR [95% CI]a | p value | OR [95% CI]a | p value | |
| B*40:02 | M1 | 3.51 [1.7–7.3] | 0.0008 | 4.05 [0.7–24.6] | 0.128 | 3.42 [1.5–7.7] | 0.005 |
| DPB1*01:01 | M2 | 0.43 [0.3–0.7] | 0.0015 | 0.43 [0.2–1.0] | 0.058 | 0.43 [0.2–0.8] | 0.010 |
| DQA1*01:02 | M3 | 1.41 [1.1–1.8] | 0.007 | 1.31 [0.9–1.8] | 0.119 | 1.54 [1.1–2.2] | 0.022 |
| A*23:01 | M2 | 2.22 [1.2–4.0] | 0.007 | 2.14 [0.7–6.6] | 0.186 | 2.25 [1.1–4.4] | 0.019 |
| DQB1*06:02 | M3 | 1.46 [1.1–2.0] | 0.013 | 1.52 [1.1–2.2] | 0.025 | 1.33 [0.8–2.2] | 0.276 |
| C*03:03 | M1 | 0.52 [0.3–0.9] | 0.015 | 0.48 [0.2–1.2] | 0.132 | 0.54 [0.3–1.0] | 0.055 |
| B*49:01 | M3 | 1.96 [1.1–3.4] | 0.019 | 1.29 [0.4–3.9] | 0.657 | 2.26 [1.2–4.3] | 0.014 |
| B*07:02 | M3 | 1.42 [1.1–1.9] | 0.021 | 1.58 [1.1–2.3] | 0.016 | 1.16 [0.7–1.9] | 0.554 |
| DRB1*15:01 | M3 | 1.38 [1.0–1.9] | 0.037 | 1.42 [1–2.1] | 0.075 | 1.32 [0.8–2.2] | 0.264 |
a
Odds ratio (OR) of being asymptomatic, i.e. OR>1 indicates that the allele is more frequent in asymptomatic individuals. CI: confidence interval.
b
For each allele, ORs and p values obtained in the US prospective and CHGE cohorts with asymptomatic or controls definitions used in the corresponding meta-analysis are given.