Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 27;19(3):2281733. doi: 10.1080/21645515.2023.2281733

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Inovio Pharmaceuticals, Inc. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

PMC Copyright notice

Figure 2. — Heterologous and homologous boost of mRNA vaccinated hamsters. (a) Study schematic²⁵ and dosing schedule in Syrian golden hamsters. (b) Neutralizing activity (ID₅₀ values) against the WT pseudovirus pre-boost (day 96) and post-boost (day 110) are shown. Each data point represents the mean of technical duplicates for each animal (n = 6). Dashed lines represent the limit of detection (LOD) of the assay. Samples below LOD were plotted at the number equivalent to half of the lowest serum dilution. Data shown represent mean ID₅₀ (GMT ± 95% CI) for each group of six hamsters. GMT numbers are plotted above bars for reference. **P < .001. 2-way ANOVA, Sidak’s multiple comparison. (c) Splenocyte cellular responses to WT spike peptide megapool on day 110 measured by IFNγ ELISpot assay. Data shown represent IFNγ spots per one million cells of experimental triplicates (mean ± SEM) after DMSO subtraction. *P < .05 student t-test, Mann Whitney.