Table 1.

Carrier frequencies of the CFTR F508del allele (i.e., F508del heterozygosity) in healthy individuals vs. individuals hospitalized with severe COVID-19 and meta-analysis for p-value of association with COVID-19 outcome. The p-value of association, corrected for multiple testing using the correction method of Benjamini-Holm (pFDR), was obtained from inverse-weighted fixed effects meta-analysis as detailed in Methods. Note: patient demographics and treatment regimens for study subjects are provided in Tables S1A, S1B, and S1C.

	Italy		Spain		Norway
	healthy	COVID-19	healthy	COVID-19	healthy	COVID-19
total	3266	1251	3449	1226	262	62
wt/wt	3211	1228	3400	1206	259	61
wt/F508del	55	23	49	20	3	1
carrier frequency, %	1.68	1.84	1.42	1.63	1.15	1.61
Meta-analysis	p = 0.205; pFDR = 1