| • Impaired pulmonary function showing airflow obstruction or restriction (or mixed abnormalities) and bronchodilator response and/or impaired DLco
|
| • Abnormal blood gas: Pao2 < 80 mmHg and/or Paco2 > 45 mmHg and/or nocturnal and exercise-induced desaturation |
| • Impaired exercise capacity |
| • Persistent respiratory symptoms (dyspnea, cough, sputum, wheezing, chest pain, and fatigue) |
| • Ineffective cough and/or difficulty to clear bronchial secretions |
| • At least one hospitalization or two exacerbations within the last 12 months |
| • Presence of comorbid conditions, including COPD, asthma, bronchiectasis, pulmonary fibrosis, pulmonary hypertension, and/or need for surgery |
| • Impaired quality of life |
