Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Epigenetic silencing of LINE-1. (A) Multiple protein complexes, including KAP1 and HUSH, function in concert to deposit repressive marks at LINE-1 sequences, such as DNA methylation via DNMTs or H3K9 trimethylation via SETDB1. (B) Shown is a working model for how epigenetic variation (e.g., alterations in DNA methylation patterns) of individual LINE-1 sequences across somatic cell types influences ORF1p expression and somatic retrotransposition in human tissues.
