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. 2024 Jan 2;19(1):e0295208. doi: 10.1371/journal.pone.0295208

Table 7. Statistical Association between DRPs and hospital-acquired infections among hospitalized stroke patients.

Primary Domain Causes Frequency of DRPs (n) Hospital acquired Infections p-value
Yes No
Drug Selection Inappropriate drug according to guidelines/formulary 86 80 06
Inappropriate combination of drugs, or drugs and herbal medications, or drugs and dietary supplements 102 74 28 0.000
Appropriate drug according to guidelines/formulary 62 20 42
Dose Selection Dosage regimen not frequent enough 132 93 39
0.000
Dosage regimen too frequent 53 31 22
Dose timing instructions wrong, unclear or missing 12 06 06
Treatment Duration Duration of treatment too short 90 63 27
Duration of treatment too long 87 67 20 0.072
Proper Duration of treatment 73 44 29
Dispensing Prescribed drug not available 47 31 16 0.003
Necessary information not provided or incorrect advice provided 120 80 40
Drug use process Inappropriate timing of administration or dosing intervals 110 84 26
0.000
Wrong drug administered 70 60 10
Appropriate timing of administration or dosing intervals 65 26 39

Table adapted from Pharmaceutical Care Network Europe (PCNE) Classification Version 9.1 45