Table 3. Univariate and multivariate analyses of OS-related factors.
| Variable | Category | Univariate analysis | P-value | Multivariate analysis | P-value |
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | Hazard ratio (95% CI) | ||||
| Age, years | <75 | 1 | |||
| ≥75 | 1.077 (0.628–1.847) | 0.786 | |||
| Sex | Male | 1 | |||
| Female | 1.444 (0.784–2.661) | 0.239 | |||
| Hypertension | Absent | 1 | |||
| Present | 0.696 (0.397–1.220) | 0.206 | |||
| Diabetes mellitus | Absent | 1 | |||
| Present | 0.810 (0.458–1.430) | 0.467 | |||
| Hyperlipidemia | Absent | 1 | 1 | ||
| Present | 2.581 (1.027–6.487) | 0.044 | 2.700 (1.055–6.911) | 0.038 | |
| Prior systemic therapy | Absent | 1 | |||
| Present | 1.100 (0636–1.902) | 0.733 | |||
| Etiology | Viral | 1 | |||
| Non-viral | 0.948 (0.789–1.139) | 0.568 | |||
| ECOG PS | 0 | 1 | |||
| 1 | 2.097 (0.946–4.647) | 0.068 | |||
| Maximum intrahepatic tumor size, mm | <50 | 1 | 1 | ||
| ≥50 | 2.438 (1.387–4.285) | 0.002 | 1.479 (0.791–2.764) | 0.220 | |
| Intrahepatic tumor number | ≤4 | 1 | 1 | ||
| ≥5 | 1.950 (1.110–3.321) | 0.02 | 2.084 (1.161–3.740) | 0.014 | |
| Macrovascular invasion | Absent | 1 | 1 | ||
| Present | 2.569 (1.426–4.628) | 0.002 | 2.128 (1.146–3.951) | 0.017 | |
| Extrahepatic metastasis | Absent | 1 | |||
| Present | 1.122 (0.652–1.932) | 0.678 | |||
| AFP, ng/mL | <400 | 1 | 1 | ||
| ≥400 | 2.307 (1.337–3.982) | 0.003 | 2.422 (1.371–4.280) | 0.002 | |
| Child–Pugh score | 5 | 1 | 1 | ||
| 6 or 7 | 2.370 (1.331–4.221) | 0.003 | 2.942 (1.594–5.429) | 0.001 | |
| mALBI grade | 1 or 2a | 1 | |||
| 2b or 3 | 1.982 (1.15–13.413) | 0.014 | |||
| NLR | <3.03 | 1 | 1 | ||
| ≥3.03 | 2.361 (1.368–4.037) | 0.002 | 1.920 (1.072–3.437) | 0.028 |
CI, confidence interval; OS, overall survival; ECOG PS, Eastern Cooperative Oncology Group performance status; ALBI, albumin-bilirubin; mALBI, modified albumin-bilirubin; AFP, α-fetoprotein; NLR, neutrophil-to-lymphocyte ratio.