Table 3. Univariate and multivariate analyses of OS-related factors.

Variable	Category	Univariate analysis	P-value	Multivariate analysis	P-value
		Hazard ratio (95% CI)		Hazard ratio (95% CI)
Age, years	<75	1
	≥75	1.077 (0.628–1.847)	0.786
Sex	Male	1
	Female	1.444 (0.784–2.661)	0.239
Hypertension	Absent	1
	Present	0.696 (0.397–1.220)	0.206
Diabetes mellitus	Absent	1
	Present	0.810 (0.458–1.430)	0.467
Hyperlipidemia	Absent	1		1
	Present	2.581 (1.027–6.487)	0.044	2.700 (1.055–6.911)	0.038
Prior systemic therapy	Absent	1
	Present	1.100 (0636–1.902)	0.733
Etiology	Viral	1
	Non-viral	0.948 (0.789–1.139)	0.568
ECOG PS	0	1
	1	2.097 (0.946–4.647)	0.068
Maximum intrahepatic tumor size, mm	<50	1		1
	≥50	2.438 (1.387–4.285)	0.002	1.479 (0.791–2.764)	0.220
Intrahepatic tumor number	≤4	1		1
	≥5	1.950 (1.110–3.321)	0.02	2.084 (1.161–3.740)	0.014
Macrovascular invasion	Absent	1		1
	Present	2.569 (1.426–4.628)	0.002	2.128 (1.146–3.951)	0.017
Extrahepatic metastasis	Absent	1
	Present	1.122 (0.652–1.932)	0.678
AFP, ng/mL	<400	1		1
	≥400	2.307 (1.337–3.982)	0.003	2.422 (1.371–4.280)	0.002
Child–Pugh score	5	1		1
	6 or 7	2.370 (1.331–4.221)	0.003	2.942 (1.594–5.429)	0.001
mALBI grade	1 or 2a	1
	2b or 3	1.982 (1.15–13.413)	0.014
NLR	<3.03	1		1
	≥3.03	2.361 (1.368–4.037)	0.002	1.920 (1.072–3.437)	0.028

CI, confidence interval; OS, overall survival; ECOG PS, Eastern Cooperative Oncology Group performance status; ALBI, albumin-bilirubin; mALBI, modified albumin-bilirubin; AFP, α-fetoprotein; NLR, neutrophil-to-lymphocyte ratio.