Table 7. Pharmacokinetics prediction output of compounds identified from raw and roasted Terminalia catappa nuts.

Compounds	P-gp substrate	Inhibitors of					Log kp
		CYP1A2	CYP2C19	CYP2C9	CYP2D6	CYP3A4
Proanthocyanin	No	No	No	No	No	Yes	-8.0
Naringin	Yes	No	No	No	No	No	10.2
Quinine	No	No	No	No	Yes	No	-6.2
Flavan-3-ol	No	No	No	No	Yes	No	-5.7
Anthocyanin	Yes	Yes	No	No	Yes	No	-5.1
Ribalinidine	Yes	Yes	No	No	No	No	-6.9
Naringenin	Yes	Yes	No	No	No	Yes	-6.2
Spartein	No	No	No	No	No	No	-5.9
Sapogenin	Yes	No	No	No	No	No	-6.6
Phenol	No	Yes	No	No	No	No	-5.8
Flavonones	No	Yes	No	No	No	No	-5.4
Steroid	Yes	No	No	No	No	No	-7.3
Epicatechin	Yes	No	No	No	No	No	-7.8
Kaempferol	No	Yes	No	No	Yes	Yes	-6.7
Phytate	Yes	No	No	No	No	No	-17.6
Flavone	No	Yes	Yes	No	No	No	-5.1
Oxalate	No	No	No	No	No	No	-7.0
Catechin	Yes	No	No	No	No	No	-7.8
Resveratrol	No	Yes	No	Yes	No	Yes	-5.5
Tannin	Yes	No	No	No	No	No	-11.7

Key: Pgp = P-glycoprotein; CYP450 = Cytochrome P450; Log kp = skin permeation.