Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Nov 20;17(1):2281714. doi: 10.1080/19336950.2023.2281714

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

PMC Copyright notice

Figure 8. — Slow inactivation and drug block of Na⁺ channels. a) top view of the collapse of the pore during slow inactivation of Na_VAb. Two S6 segments move inward the central axis of the pore and two move outward to produce an asymmetric, partially collapsed conformation. The selectivity filter structure has changed from nearly square in the pre-open state of Na_VAb/I217C to a partially collapsed parallelogram in the inactivated state of Na_VAb/WT-CD. b) the central cavity is partially collapsed. c) the activation gate is tightly closed, but collapsed into a two-fold symmetric conformation. Adapted from Payandeh et al, 2012 [102]. d) structure of Na_VAb with the selectivity filter (SF), central cavity (CC), and activation gate (AG) highlighted. e) lidocaine bound in the central cavity at the base of the selectivity filter. f) flecainide bound at the local anesthetic/antiarrhythmic receptor site in the central cavity at the base of the selectivity Filter.