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. 2023 Aug 23;20(1):45–57. doi: 10.1080/15548627.2023.2247310

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — Rapamycin has a positive impact on autophagy-deficient HSC function upon transplantation. (A) Experimental setup. (B) Ratios of PTPRC^b/CD45.2: PTPRC^a/CD45.1 WT cells prior to BM transplantation. (C) Contribution of WT (PTPRC^a/CD45.1) and autophagy deficient Vav^Cre atg7^fl/fl or WT (PTPRC^b/CD45.2) cells to the myeloid (ITGAM/CD11b⁺), B cell (CD19⁺) and T cell (TCRb⁺) compartments in recipient mice (n = 8–10/animals per group). (D) Frequencies of PTPRC^b/CD45.2 LSKs and HSCs in the BM of recipient mice 12 weeks after transplantation (n = 3–5 animals/group). Data are represented as mean ± SEM with two-tailed unpaired Student’s t test.