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. 2023 Oct 31;11:rbad096. doi: 10.1093/rb/rbad096

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© The Author(s) 2023. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Micro-CT evaluation of in vivo bone regeneration of critical-sized calvarial defects. Two full-thickness defects (4 mm in diameter) were drilled on rat calvarium. PLLA/HA and PLLA/HA@Irisin nanofibrous membranes were in situ implanted. The untreated defects served as the defect group. (A) Schematic diagram of surgery and implantation process. (B) At 4 and 8 weeks post-surgery, the new bone formation in the calvarial defect was evaluated by micro-CT imaging and 3D reconstruction. Quantitative analysis of (C) BMD, (D) bone volume ratio (BV/TV) and (E) Tb.Th in the defect area after 4 and 8 weeks of implantation, n = 3. Statistically significant differences were indicated by *P < 0.05 or **P < 0.01.