Table 3. Area of NB by bone block substitutes with rhBMP-2 (in mm2).
| Variables | DBBM | PBC | PB | PBC+M | Friedman test | |
|---|---|---|---|---|---|---|
| 2 weeks | n=8 | n=6 | n=8 | n=6 | ||
| NB | 1.44±0.64, 1.43 (0.91–1.95) | 1.39±0.49, 1.30 (1.10–1.68) | 1.46±0.43, 1.59 (1.06–1.78) | 2.19±1.20, 1.97 (1.49–3.11) | P=0.165 | |
| Intergroup comparison | N/A | N/A | N/A | N/A | ||
| NB_in | 0.88±0.45, 0.84 (0.56–1.13) | 0.91±0.38, 0.84 (0.60–1.19) | 0.89±0.49, 0.82 (0.58–1.09) | 1.20±1.01, 1.11 (0.37–1.86) | P=0.196 | |
| Intergroup comparison | N/A | N/A | N/A | N/A | ||
| NB_out | 0.56±0.43, 0.61 (0.18–0.77) | 0.48±0.23, 0.51 (0.31–0.68) | 0.57±0.55, 0.30 (0.22–0.91) | 0.97±0.52, 1.15 (0.70–1.32) | P=0.075 | |
| Intergroup comparison | N/A | N/A | N/A | N/A | ||
| 12 weeks | n=7 | n=8 | n=7 | n=7 | ||
| NB | 3.60±0.87, 3.21 (3.01–3.99) | 4.74±1.15, 5.08 (4.35–5.39) | 4.56±0.89, 4.71 (4.29–5.11) | 5.91±2.26, 5.55 (4.50–7.43) | P=0.029 | |
| Intergroup comparison | P=0.018 (vs. PBC) | P=0.018 (vs. DBBM) | P=0.028 (vs. DBBM) | P=0.043 (vs. DBBM) | ||
| P=0.028 (vs. PB) | P=0.735 (vs. PB) | P=0.735 (vs. PBC) | P=0.499 (vs. PBC) | |||
| P=0.043 (vs. PBC+M) | P=0.499 (vs. PBC+M) | P=0.600 (vs. PBC+M) | P=0.600 (vs. PB) | |||
| NB_in | 2.88±1.49, 3.12 (2.54–3.65) | 3.64±2.25, 4.77 (3.36–4.92) | 3.38±1.68, 4.30 (3.00–4.39) | 4.67±2.84, 4.88 (3.28–6.48) | P=0.219 | |
| Intergroup comparison | N/A | N/A | N/A | N/A | ||
| NB_out | 0.73±1.05, 0.36 (0.23–0.58) | 1.10±1.23, 0.67 (0.22–1.32) | 1.17±1.60, 0.50 (0.34–1.07) | 1.24±1.57, 0.65 (0.59–0.99) | P=0.706 | |
| Intergroup comparison | N/A | N/A | N/A | N/A | ||
| 2 weeks vs. 12 weeks | ||||||
| NB | P=0.001 | P=0.002 | P=0.001 | P=0.007 | ||
| NB-in | P=0.021 | P=0.121 | P=0.021 | P=0.032 | ||
| NB_out | P=0.602 | P=0.518 | P=0.487 | P=0.668 | ||
Data are mean±standard deviation, median (interquartile range) values in mm2.
NB: newly formed bone, rhBMP-2: recombinant human bone morphogenetic protein-2, NB_in: area of NB in the inner part of the bone block, NB_out: area of NB in the outer part of the bone block, DBBM: deproteinized bovine bone mineral block, PBC: porcine bone block with collagen matrix incorporation, PB: porcine bone block without collagen matrix incorporation, PBC+M: PBC block covered by a collagen membrane, N/A: not applicable.