Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 4;25(1):142–154. doi: 10.1038/s41590-023-01690-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 3 — a, Frequencies of T1, T2 and FO B cells in total splenocytes in Gna13^cKO (n = 9) and control (n = 10) mice. b, Frequencies of B1a and B1b cells in total splenocytes in Gna13^cKO (n = 13) and control (n = 14) mice. c, Representative distribution patterns of IgM^hi MZ B (red) relative to IgD^hi FO B cells (blue) in full spleen cross-sections from mice of the indicated genotypes. Scale bar, 500 μm. d,e, Representative flow cytometry profiles (d) and frequencies of MZ B in total CD19⁺ B cells (e left panel), and in total splenocytes (e right panel) in Gna12^−/− (n = 8) and control (n = 5) chimeras. f, Representative distribution patterns of IgM^hi MZ B (red) relative to IgD^hi FO B cells (blue) in full spleen cross-sections from mice of the indicated genotypes. Scale bar, 500 μm. g, Frequencies of T1, T2 and FO B cells in total splenocytes in Arhgef1^−/− (n = 7) and control (n = 7) mice. h, Frequencies of B1a and B1b cells in total splenocytes in Arhgef1^−/− (n = 6) and control (n = 6) mice. Data are pooled from two (a, e, g, h) or three (b) independent experiments. Sections are representative of multiple cross-sections from at least three mice of each type (c, f). Each symbol represents one mouse and lines denote means. Statistical significance was tested by two-way ANOVA followed by Sidak’s multiple comparisons test (a, b, g, h) or two-tailed t-test (e).

Source data