Table 2.
Bleeding and thrombosis events
| Thrombocytopenia n = 274 | Control n = 796 | |
|---|---|---|
| Total bleeding events, n | 65 | 132 |
| Median platelet count, × 103/μL | 130 | 234 |
| Bleeding type, n (%) | ||
| Major | 36 (55.4) | 45 (34.1) |
| Fatal | 1 (1.5) | 3 (2.3) |
| Bleeding into critical area∗ | 6 (9.2) | 8 (6.1) |
| Overt bleeding† | 28 (43.1) | 31 (23.5) |
| CRNMB | 29 (44.6) | 87 (65.9) |
| Location of bleed, n (%) | ||
| Mucocutaneous | 17 (26.2) | 60 (45.1) |
| Gastrointestinal | 21 (32.3) | 45 (33.8) |
| Intracranial | 3 (4.6) | 7 (5.3) |
| Pulmonary | 3 (4.6) | 7 (5.3) |
| Intramuscular | 5 (7.7) | 4 (3.0) |
| Retroperitoneal | 2 (3.1) | 2 (1.5) |
| Pericardial | 2 (3.1) | 1 (0.8) |
| Other | 12 (18.5) | 6 (4.5) |
| Total thrombosis events, n | 19 | 20 |
| Venous, n (%) | 10 (52.6) | 7 (35.0) |
| Deep vein thrombosis | 4 (21.1) | 5 (25.0) |
| Pulmonary embolism | 2 (10.5) | 0 (0.0) |
| Other | 4 (21.1) | 2 (10.0) |
| Arterial, n (%) | 9 (47.4) | 13 (65.0) |
| Ischemic stroke | 4 (21.1) | 6 (30.0) |
| Acute coronary syndrome | 3 (15.8) | 2 (10.0) |
| Other | 2 (10.5) | 5 (25.0) |
∗
Defined by International Society on Thrombosis and Haemostasis (ISTH) as the following spaces: intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, or intramuscular with compartment syndrome.
†
Defined by ISTH as bleeding causing a drop in hemoglobin ≥2g/dL or leading to a transfusion of at least 2 units of red blood cells.