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. 2023 Dec 20;14:1301991. doi: 10.3389/fimmu.2023.1301991

Figure 4.

Figure 4

Association of immune markers with clinical features and Tregs in sarcoidosis. (A), Treg suppressive function was lower in patients with thoracic lymphadenopathy (LAN+) compared to patients without thoracic lymphadenopathy (LAN-). Data for CD4+ and CD8+ T cell responders in Treg suppression assays are combined. (B), Plasma levels of TNFα, sCD25/IL-2Rα, and TNFR I and II, evaluated by Luminex assay, were higher in LAN+ (n =18) compared to LAN- (n = 9) patients. Expression of Ki-67 in PBMCs and Treg numbers in CD4+ T cells, evaluated by flow cytometry, were compared between LAN+ (n = 19) and LAN- (n = 9) patients. (C), Treg suppressive function in sarcoidosis patients was inversely correlated with the number of pulmonary symptoms, n = 18. (D), Ki-67 expression was positively correlated with the number of pulmonary symptoms, n = 30. (E), Treg suppressive function was decreased in patients with more than one systemic symptom (n = 6) compared to patients with 0-1 systemic symptoms (n = 21). Data for CD4+ and CD8+ responders in Treg suppression assays are combined. (A) - unpaired T test; (B) (TNFα, sCD25, TNFR I and II, Ki-67 in PBMC) - Mann-Whitney test; (B) (Tregs in CD4+ cells) - unpaired T test with Welch’s correction; (C, D) - Spearman’s correlation; (E) – Mann-Whitney test.