Table 4.

Kinetic parameters estimates from 14 ROIs, gray and white matter and whole brain

	2TCM (24 min short window)				Patlak (validation window) $K_i$(ml/g/min)	Relative error (%) in $K_i$ (short window against validation window)
Region	$K_1$(ml/g/min)	$k_2$(1/min)	$k_3$(1/min)	$K_i$(ml/g/min)
Caudate	0.07 ± 0.02	0.11 ± 0.04	0.04 ± 0.02	0.020 ± 0.007	0.020 ± 0.006	0.5 ± 3.8
Cerebellum	0.10 ± 0.04	0.16 ± 0.07	0.04 ± 0.02	0.018 ± 0.007	0.017 ± 0.005	3.3 ± 8.5
Cingulum Ant	0.08 ± 0.03	0.12 ± 0.04	0.05 ± 0.02	0.025 ± 0.008	0.023 ± 0.006	7.2 ± 4.2
Cingulum Post	0.08 ± 0.03	0.12 ± 0.05	0.05 ± 0.02	0.021 ± 0.009	0.021 ± 0.008	1.3 ± 2.4
Hippocampus	0.08 ± 0.02	0.12 ± 0.04	0.04 ± 0.02	0.018 ± 0.007	0.018 ± 0.005	− 0.2 ± 5.3
Insula	0.08 ± 0.02	0.12 ± 0.04	0.05 ± 0.02	0.024 ± 0.007	0.022 ± 0.005	6.9 ± 3.6
Putamen	0.08 ± 0.02	0.12 ± 0.04	0.05 ± 0.01	0.023 ± 0.007	0.022 ± 0.005	8.0 ± 4.6
Occipital	0.08 ± 0.03	0.12 ± 0.04	0.05 ± 0.02	0.023 ± 0.008	0.023 ± 0.006	1.3 ± 4.1
Parietal	0.08 ± 0.02	0.1 ± 0.03	0.05 ± 0.02	0.024 ± 0.007	0.024 ± 0.006	2.0 ± 4.0
Lingual	0.09 ± 0.03	0.13 ± 0.05	0.05 ± 0.02	0.024 ± 0.007	0.023 ± 0.006	5.3 ± 3.3
Temporal Mid	0.08 ± 0.02	0.11 ± 0.04	0.05 ± 0.02	0.022 ± 0.008	0.022 ± 0.006	2.0 ± 3.6
Amygdala	0.08 ± 0.03	0.12 ± 0.06	0.04 ± 0.02	0.020 ± 0.008	0.020 ± 0.007	0.2 ± 4.5
Thalamus	0.08 ± 0.02	0.11 ± 0.04	0.05 ± 0.01	0.021 ± 0.006	0.020 ± 0.005	6.3 ± 4.2
White matter	0.05 ± 0.01	0.07 ± 0.02	0.03 ± 0.01	0.012 ± 0.004	0.014 ± 0.003	− 17.3 ± 15.4
Gray Matter	0.08 ± 0.03	0.11 ± 0.04	0.04 ± 0.02	0.021 ± 0.008	0.021 ± 0.006	2.0 ± 5.0
Whole Brain (mean)	0.08 ± 0.02	0.12 ± 0.04	0.04 ± 0.02	0.021 ± 0.007	0.021 ± 0.006	1.9 ± 5.1