Table 3.
Sensitivity analysis censoring the NED by multivariable Cox regression for mortality by centile of TC.
| No. of patients | Events | Person-years | Incidence rate (per 10,000 py) | Age and sex-adjusted HR (95% CI) | Multivariable-adjusted HR (95% CI) | |
|---|---|---|---|---|---|---|
| 1st–5th (≤ 97 mg/dL) | 3012 | 894 | 10,467 | 854.2 | 1.86 (1.71–2.02) | 1.60 (1.46–1.74) |
| 6th–20th (97–128 mg/dL) | 9217 | 2051 | 32,517 | 630.7 | 1.52 (1.42–1.62) | 1.29 (1.20–1.38) |
| 21st–40th (129–151 mg/dL) | 12,006 | 2030 | 44,129 | 460.0 | 1.20 (1.12–1.29) | 1.08 (1.01–1.16) |
| 41st–60th (152–171 mg/dL) | 11,467 | 1690 | 42,565 | 397.0 | 1.13 (1.05–1.21) | 1.06 (0.99–1.13) |
| 61st–80th (172–196 mg/dL) | 11,903 | 1466 | 44,807 | 327.2 | Reference | Reference |
| 81st–95th (197–233 mg/dL) | 8690 | 996 | 33,300 | 299.1 | 0.96 (0.88–1.04) | 1.03 (0.95–1.11) |
| 96th–100th (> 233 mg/dL) | 2922 | 410 | 11,228 | 365.1 | 1.25 (1.12–1.39) | 1.35 (1.21–1.51) |
Multivariable-adjusted model was adjusted for age, sex, BMI, use of lipid-lowering agents, presence of CKD, DM, and HTN, smoking status, alcohol consumption, and cancer type.
CKD chronic kidney disease, DM diabetes mellitus, HR hazard ratio, HTN hypertension, NED no evidence of disease, TC total cholesterol, CI confidence interval.