Table 2.

Mendelian randomization estimates for causal effects of TRP on IBD.

Exposure	Outcome	Method	OR	95% CI	P value
TRP	IBD	IVW	0.739	0.697–0.783	1.19e−24
		MR-Egger	0.471	0.295–0.753	2.09e−03
		Weighted median	0.770	0.713–0.831	2.10e−11
		Simple mode	0.771	0.625–0.952	1.72e−02
		Weighted mode	0.771	0.635–0.938	1.04e−02
	UC	IVW	0.875	0.814–0.942	3.95e−04
		MR-Egger	0.586	0.323–1.063	8.13e−02
		Weighted median	0.849	0.774–0.932	6.17e−04
		Simple mode	0.814	0.644–1.028	8.68e−02
		Weighted mode	0.814	0.636–1.041	1.04e−01
	CD	IVW	0.685	0.613–0.765	2.56e−11
		MR-Egger	0.962	0.390–2.373	9.34e−01
		Weighted median	0.625	0.539–0.725	5.87e−10
		Simple mode	0.619	0.421–0.912	1.67e−02
		Weighted mode	0.619	0.420–0.913	1.71e−02

IBD inflammatory bowel disease, UC ulcerative colitis, CD Crohn’s disease, TRY tryptophan.