Table 4.
Heterogeneity and pleiotropy analysis of TRP and KYN with IBD, UC and CD.
| Exposure | Outcome | MR-Egger | IVW | ||||
|---|---|---|---|---|---|---|---|
| Intercept | Pleiotropy | Cochran’s Q | Heterogeneity | Cochran’s Q | Heterogeneity | ||
| p value | Statistic | p value | Statistic | p value | |||
| TRP | IBD | 0.051 | 0.060 | 16.817 | 1 | 20.406 | 1 |
| UC | 0.046 | 0.185 | 3.665 | 1 | 5.437 | 1 | |
| CD | − 0.039 | 0.457 | 16.951 | 1 | 17.506 | 1 | |
| KYN | IBD | 0.012 | 0.452 | 59.876 | 5.50e−3 | 60.861 | 5.93e−3 |
| UC | 0.014 | 0.264 | 36.081 | 0.603 | 37.361 | 0.589 | |
| CD | 0.001 | 0.938 | 36.929 | 0.379 | 36.935 | 0.452 | |
IBD inflammatory bowel disease, UC ulcerative colitis, CD Crohn’s disease, TRY tryptophan, KYN kynurenine.