Fig. 7.

Sh-NRF2 with AAV abolishes the anti-AS effect of MCL in ApoE^−/− mice. ApoE^−/− mice were divided into two groups and received MCL gavage. The two groups were injected with AAV-sh-NC and AAV-sh-NRF2 via rat tail vein, respectively. After 16 weeks, artery was taken from the mice. (A) Gross morphology of mouse aortic arch. N = 3; (B–D). Representative images for HE, Masson, and Oil red O stain in aortic roots. N = 3; (E). Oil red O staining of mouse aortas surface. N = 3; (F). IL-1β level in serum. N = 5; (G). TNF-α level in serum. N = 5; (H). IL-4 level in serum. N = 5; (I). IL-10 level in serum. N = 5. ***p < 0.001 vs sh-NC/MCL.