Table 2.

Possibility for targeting zinc metabolism in multiple diseases

Protein	Disease	Expression	Current or potential targeting value
ZIP5	Diabetes	Downregulated	The potential therapeutic target for diabetes-related diseases.185
ZIP10	Hematopoietic disease	Downregulated	Targeting ZIP10 may be a new therapeutic strategy against early fetal anemia.50
ZIP14	Dystrophic muscles	Upregulated	Underscores the importance of regulated zinc homeostasis in metastatic cancer-induced muscle dystrophy and suggests a novel treatment avenue by targeting ZIP14.50
	Liver cirrhosis	Upregulated	A new potential therapeutic avenue for preventing iron-death-induced liver fibrosis.185
ZnT8	Diabetes	Downregulated	To achieve more accurate early classification of diabetes and identification of which patients will rapidly require insulin treatment (NCT02287506). The usefulness of Intermittently Scanned Continuous Glucose Monitoring in the Diagnosis of Maturity-onset Diabetes of the Young (MODY) Patients (NCT05918484). The Mechanism of TCF7L2 and ZnT8 on Antipsychotic-induced Metabolic Syndrome (NCT02093858). Study whether ZIP8 rs13266634 polymorphism is associated with T2DM susceptibility and study the effect of zinc supplementation on glycemic control in patients with type 2 diabetes (NCT03112382, phase 4).
MT1/2	AD	–	Modulation of MT-I/II expression is a potential therapeutic target to treat the onset and progression of cognitive impairment.618–620
	Ocular neovascularization	–	MT1/2 is a potential novel therapeutic target for diseases involving ocular angiogenesis.50