Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 2;15:117. doi: 10.1038/s41467-023-44411-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Expression analysis of human FAM161A (hFAM161A) type 2 (second panel from left), house mouse FAM161A (mFAM161A) type 2 (middle three panels), mFAM161A type 3 (second panel from right), and the combination of mFAM161A types 2 and 3 (right panel) in U2OS cells. b Quantification showing the percentage of cells exhibiting each of the various expression patterns observed during expression analysis of hFAM161A type 2, mFAM161A type 2, mFAM161A type 3, and the combination of mFAM161A types 2 and 3. C, “Cytoplasmic”; I, “Intranuclear”; I + P, “Mix intranuclear-perinuclear”; P, “Perinuclear”. c Quantification of FAM161A colocalization with tubulin. ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05 (unpaired, two-tailed t test; exact p-values are provided in the Source Data File); ns not significant, n number of cells, scale bars are 8 µm. The data shown are the representative images and compiled quantification from three independent experiments. Data are presented as box and whisker plots, where upper and lower bounds show interquartile range, the line within the box shows the median, and whiskers show minimum and maximum data points. d Co-overexpression of FAM161A isoforms and POC5 in U2OS cells. The inset in the bottom left corner shows a zoomed view of the site of the centriole, and the inset in the bottom right corner shows a zoomed view of non-centriolar POC5 locations in the cell. Scale bars are 8 µm, inset scale bar is 1 µm. e Quantification showing the percentage of cells exhibiting the various expression patterns observed during expression analysis of hFAM161A type 2, mFAM161A type 2, and mFAM161A type 3. Ce, “Centriolar”; Ce+A, “Centriolar + Aggregate”; C, “Cytoplasmic”; Pc, “Partial Cytoplasmic”; A + C, “Aggregate + Cytoplasmic”; P, “Perinuclear”. f Quantification of FAM161A colocalization with POC5. Statistical analysis used was unpaired, two-tailed t test. Source data are provided in the Source Data File.