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. 2024 Jan 2;15:108. doi: 10.1038/s41467-023-44601-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Phylogenetic analysis of the structurally conserved residues of human aminergic receptors using the GPCRdb tool (Top). hTA1 is circled for orientation. Sequence similarity and identity calculated for complete receptor sequences or only structurally conserved positions (bottom). B Structural comparison of the hTA1-Gs and 5-HT4R-Gs (PDB: 7XT8) complexes and superposition of the receptors shown from different angles. Light blue, hTA1; dark blue, 5-HT4R; Ro5256390, magenta; orange, serotonin; Gαs, green; Gβ1, salmon; Gγ2, purple.