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. 2024 Jan 2;10(1):2. doi: 10.1038/s41514-023-00133-1

Fig. 6. NMN increase in mouse plasma after oral gavage of NMN.

Fig. 6

Five- to six month-old (young, n = 9) or 24 to 25 month-old (old, n = 7) C57BL/6 J male mice were orally given NMN at 300 mg/kg. Blood was collected from the tail vein at indicated time points. Plasma was extracted with PCA and analyzed with dimeLC-MS/MS. Data are presented as mean ± SEM. Statistical analysis was conducted using repeated-measures two-way ANOVA with Bonferroni’s multiple comparisons post hoc test. a Recovery efficiencies for NMN (M + 14) in young and old plasma extracts are shown. b Changes in plasma NMN concentrations after oral gavage in young and old mice. *p < 0.05 between young mice and old mice at 5 min time point. #p < 0.05 between 0 and 5 min time points in young mice. c Changes in plasma NAM, NA and NR concentrations in young and old mice. Statistical significances at 5 and 15 min time points are shown against 0 min time point for NAM. **p < 0.005, ***p < 0.0005, ****p < 0.0001.