Table 2.
The association between mentioned SNPs and risk of stroke in allelic, co-dominant, dominant and recessive models.
| Model | Control n = 150 | Stroke n = 100 | P-value | OR (95% CI) | ||
|---|---|---|---|---|---|---|
| n (%) | n (%) | |||||
|
MTHFR C677T |
General | CC | 70 (46.7) | 8 (8.0) | Reference | |
| CT | 71 (47.3) | 81 (81.0) | < 0.001 | 3.856 (2.518–5.905) | ||
| TT | 9 (6.0) | 11 (11.0) | < 0.001 | 4.026 (2.066–5.905) | ||
| Recessive | CC + CT Vs TT | 141 (94) | 89 (89) | Reference | ||
| 9 (6.0) | 11 (11.0) | 0.159 | 1.511 (0.850–2.685) | |||
| Over-dominant | CC + TT Vs CT | 79 (52.7) | 19 (19) | Reference | ||
| 71 (47.3) | 81 (81.0) | < 0.001 | 2.576 (1.819–3.647) | |||
| Dominant | CC Vs CT + TT | 70 (46.7) | 8 (8.0) | Reference | ||
| 80 (53.3) | 92 (92) | < 0.001 | 3.875 (2.544–5.803) | |||
| Allelic | C-Allele | 211 (70.3) | 97 (48.5) | Reference | ||
| T-Allele | 89 (29.7) | 103 (51.5) | < 0.001 | 2.517 (1.736–3.651) | ||
|
MTHFR A1298C |
General | AA | 68 (45.3) | 11 (11.0) | Reference | |
| AC | 73 (48.7) | 88 (88.0) | < 0.001 | 3.323 (2.238–4.933) | ||
| CC | 9 (6.0) | 1 (1.0) | 0.728 | 0.821 (0.269–2.500) | ||
| Recessive | AA + AC Vs CC | 141 (94) | 99 (99) | Reference | ||
| 9 (6.0) | 1 (1.0) | 0.083 | 0.346 (0.119–1.011) | |||
| Over-dominant | AA + CC Vs AC | 77 (51.3) | 12 (12) | Reference | ||
| 73 (48.7) | 88 (88.0) | < 0.001 | 3.390 (2.318–4.959) | |||
| Dominant | AA Vs AC + CC | 68 (45.3) | 11 (11.0) | Reference | ||
| 82 (54.7) | 89 (89) | < 0.001 | 3.111 (2.102–4.606) | |||
| Allelic | A-Allele | 209 (69.7) | 110 (55.0) | Reference | ||
| C-Allele | 91 (30.3) | 90 (45.0) | < 0.001 | 1.879 (1.296–2.725) | ||
OR odd ratio, P probability; P < 0.05 significant, Regression analysis was used.