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. 2024 Jan 2;15:136. doi: 10.1038/s41467-023-44506-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Region of human chromosome 7 containing a large 500 kb window lacking any annotated protein-coding genes with extensive enrichment of activated enhancer (yellow and orange) and transcriptionally active (green) segment annotations in human craniofacial tissue. CS (Carnegie stage). Locations of human embryonic craniofacial superenhancers (heCFSE) are represented by orange bars, human embryonic heart superenhancers (heHSE) by dark pink bars and superenhancers found in the dbSuper database by black bars. b Enlargement of two superenhancers with multiple validated craniofacial enhancer segments. Enhancers with mm or hs designations were identified through the Vista Enhancer Browser (c). In this study we tested and validated the craniofacial enhancer activity of HACNS50, located within the bivalent chromatin state at the right of the enlargement.