Fig. 6. AKAs alter myeloid cell metabolism in lesions during remyelination.

a Experimental design for myeloid cell isolation from mouse spinal cord lesions and Nanostring metabolic transcriptomic profiling. Volcano plot (b) and heatmap (c, t test, p < 0.05) for lesions and adjacent non-lesion tissues. d Violin plot for top 9 differentially expressed genes between lesion and adjacent non-lesion tissues (n = 2, each n was obtained from 3–5 mice, t test, p < 0.05). Volcano plot (e) and heatmap (f) for differential gene expression between lesions from PBS-treated and AKAs-treated mice (t test, p < 0.05). g Violin plot for top 9 differentially expressed genes between lesions from PBS-treated and AKAs-treated mice (n = 2, each n was obtained from 3–5 mice, t test, p < 0.05).