Table 2.

AKA association with MRI volumetrics.

Outcomea	PPA		PPA/phenylalanine		HPPA		HPPA/tyrosine
	Beta (95% CI)	p valueb	Beta (95% CI)	p valueb	Beta (95% CI)	p valueb	Beta (95% CI)	p valueb
Cortical GM	0.003 (−2e−04 to 0.006)	0.06	0.003 (−3e-04 to 0.006)	0.07	0.003 (−7e−04 to 0.006)	0.12	0.003 (−8e-04 to 0.006)	0.13
Cerebral WM	0.005 (4e−04 to 0.009)	0.03	0.003 (−9e-04 to 0.008)	0.12	0.003 (−0.002 to 0.007)	0.24	0.003 (−0.001 to 0.007)	0.14
Subcortical GM	3e-04 (−2e−04 to 7e-04)	0.29	2e-04 (−2e-04 to 7e-04)	0.31	2e-04 (−2e−04 to 7e-04)	0.31	2e-04 (−2e-04 to 7e-04)	0.32
WBV	0.007 (−1e−04 to 0.014)	0.053	0.006 (−0.002 to 0.013)	0.13	0.006 (−0.001 to 0.013)	0.11	0.006 (−0.001 to 0.013)	0.1
T2 lesion	−0.002 (−0.003 to −4e−04)	0.01	−0.002 (−0.003 to -3e-04)	0.02	−0.001 (−0.003 to 1e-04)	0.06	−0.0011 (−0.003 to 3e-04)	0.13

Statistically significant values (<0.05) are bolded.

GM gray matter, HPPA 4-hydroxyphenylpyruvate, PPA phenylpyruvate, WBV whole brain volume, WM white matter.

^aAll MRI volumes are expressed as ratio of intracranial volume.

^bp values derived from linear regression models adjusted for sex, age, and MS type.