Fig. 3.

Interaction patterns of mGlu2 homodimers and its complex with its truncated isoform. (A-B) Top view of the conformations of mGlu2-mGlu2 (A) and the most stable complex models of mGlu2-Iso_2TM (B), identified by binding free energy calculations. The display style is the same as Fig. 2A. (C-D) Side view of the interfaces of and mGlu2-Iso_2TM Model LD-15 (C) and Model CP-H10 (D). Here the dash rectangles indicate the interface extracellular regions. The display style is the same as Fig. 2D. (E-F) mGlu2 homodimerization interface (E: Inactive; F: Active) could be blocked by Iso_2TM, shown as top view. The display style is the same as Fig. 2F.