Fig. 4.

Interaction patterns of SMO homodimers and its complex with its truncated isoform. (A-B) Top view of the conformations of SMO-SMO (A) and the most stable complex model of SMO-Iso_3TM (B), identified by binding free energy calculations. The display style is the same as Fig. 2A. (C) Side view of the interfaces of and SMO-Iso_3TM. The display style is the same as Fig. 2D. (D) SMO homodimerization interface could be blocked by Iso_3TM, shown as top view. The display style is the same as Fig. 2F.