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. 2023 Oct 30;12(1):7–16. doi: 10.1158/2326-6066.CIR-23-0321

Figure 3.

Figure 3. Inhibiting cell death confers cancer's proliferative capacity and ability to hide from immune-mediated detection and attack. Cancer cells evade immunogenic cell death by downregulating the initiation and execution of cell death. In addition to downregulating the cell death machinery via (epi)genetics, a variety of cancers employ tumor-intrinsic oncogenic pathways to selectively shut off ICD. In some cases, the immunosuppressive microenvironment renders ICD-primed antitumor cells to lose functionality.

Inhibiting cell death confers cancer's proliferative capacity and ability to hide from immune-mediated detection and attack. Cancer cells evade immunogenic cell death by downregulating the initiation and execution of cell death. In addition to downregulating the cell death machinery via (epi)genetics, a variety of cancers employ tumor-intrinsic oncogenic pathways to selectively shut off ICD. In some cases, the immunosuppressive microenvironment renders ICD-primed antitumor cells to lose functionality.