Table 1.

Painkillers and numbers needed to treat

Drug	Drug class	NNT	Ref.
Acetaminophen 650 mg + oxycodone 10 mg	NSAID + opioid	2.7	Gaskell et al[178], 2009
Acetaminophen 500 mg + ibuprofen 200 mg	NSAID combination	1.6	Moore and Hersh[179], 2013
Aspirin 1200 mg	NSAID	2.4	Bandolier Extra[180], 2003
Codeine 60 mg	Opioid	16.7	Maxwell and Bateman[181], 2007
Diclofenac 100 mg	NSAID	1.8	Gaskell et al[178], 2009
Ibuprofen 400 mg	NSAID	2.5	Lyngstad et al[182], 2021
Morphine 10 mg (intramuscular)	Opioid	2.9	Bandolier Extra[180], 2003
Naproxen 500 mg	NSAID	2.7	Derry et al[183], 2009
Oxycodone 15 mg	Opioid	4.6	Gaskell et al[178], 2009

NSAIDs: Nonsteroidal anti-inflammatory drugs; NNT: Number needed to treat.