Table 1. Baseline Characteristics.
| Characteristic | Participants, No. (%) (N = 1102) | P value | |
|---|---|---|---|
| ≤71 y (n = 555) | >71 y (n = 547) | ||
| Sex | |||
| Female | 238 (42.9) | 310 (56.7) | <.001 |
| Male | 317 (57.1) | 237 (43.3) | |
| Prestroke mRS scorea | |||
| 0 | 487 (87.7) | 407 (74.4) | <.001 |
| 1 | 51 (9.2) | 85 (15.7) | |
| 2 | 16 (2.9) | 50 (9.1) | |
| 3 | 0 | 3 (1.0) | |
| Baseline NIHSS score, median (IQR)b | 17 (12-21) | 17 (13-21) | .06 |
| Comorbidities | |||
| Current smoker | 198 (35.7) | 34 (6.2) | <.001 |
| Peripheral vascular disease | 26 (4.7) | 33 (6.1) | .30 |
| Hypertension | 321 (57.8) | 451 (82.4) | <.001 |
| Hyperlipidemia | 221 (39.8) | 293 (53.6) | <.001 |
| Diabetes | |||
| Type 1 | 4 (1.0) | 4 (1.0) | .01 |
| Type 2 | 86 (15.5) | 123 (22.5) | |
| Atrial fibrillation | 122 (22.0) | 265 (48.4) | <.001 |
| Baseline ASPECTS, median (IQR)c | 8 (7-8) | 8 (7-9) | <.001 |
| Total Fazekas scored | |||
| 0-1 | 444 (80.0) | 252 (46.1) | <.001 |
| 2 | 63 (11.4) | 148 (27.1) | |
| 3-6 | 48 (8.6) | 147 (26.9) | |
| Global cortical atrophy scoree | |||
| 0 | 518 (93.3) | 300 (54.8) | <.001 |
| 1 | 34 (6.1) | 186 (34.0) | |
| 2 or 3 | 3 (1.0) | 61 (11.2) | |
| CC/IT ratio, median (IQR) | 0.10 (0.09-0.13) | 0.14 (0.12-0.17) | <.001 |
| Lacunes present | 97 (17.5) | 175 (32.0) | <.001 |
| ≥1 Chronic infarction | 57 (10.3) | 72 (13.2) | .14 |
| Final infarction volume, median (IQR), mLf | 27 (9-86) | 5 (22-99) | .04 |
| Collaterals | |||
| Good | 101 (18.2) | 89 (16.3) | .52 |
| Moderate | 419 (75.5) | 433 (79.2) | |
| Poor | 26 (4.7) | 22 (4.0) | |
| Intracranial occlusion location | |||
| ICA | 134 (24.1) | 121 (22.1) | .41 |
| M1 branch of middle cerebral artery | 395 (71.2) | 404 (73.9) | |
| Intravenous nerinetide treatment | 265 (47.7) | 284 (51.9) | .17 |
| Intravenous alteplase treatment | 345 (62.2) | 312 (57.0) | .08 |
Abbreviations: ASPECTS, Alberta Stroke Program Early Computed Tomography Score; CC/IT, intercaudate distance to inner table width; ICA, internal carotid artery; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.
Scores range from 0 to 6, with 0 indicating perfect health without symptoms and 6 indicating death.
Scores range from 0 to 42, with higher scores indicating severe stroke.
Scores range from 0 to 10, with lower scores indicating more middle cerebral artery regions involved.
This scale evaluates the degree of white matter disease (WMD) in both periventricular and deep locations, with the score for each location ranging from 0 (no WMD) to 3 (large confluent areas or hypodensities extending to the cortex), combined to generate a total WMD-burden score.
This pragmatic, qualitative scale evaluates the degree of cortical atrophy by assessing the width of the sulci and the volume of the gyri, ranging from 0 for no atrophy to 3 for severe atrophy.
Volumes are rounded to whole numbers.