Table 2. Effect Estimates for Each Pathway in the Mediation Modelsa.
| Frailty model | β Coefficient (95% CI) | P value |
|---|---|---|
| Neuroimaging | ||
| Direct effect | 0.01 (−0.01 to 0.03) | .49 |
| Indirect effect | 0.04 (0.02 to 0.06) | <.001 |
| Total effect | 0.05 (0.04 to 0.06) | <.001 |
| Relative proportion of indirect effect, %b | 85.1 | NA |
| Composite | ||
| Direct effect | −0.02 (−0.01 to 0.03) | .26 |
| Indirect effect | 0.07 (0.03 to 0.10) | .001 |
| Total effect | 0.05 (0.04 to 0.06) | <.001 |
| Relative proportion of indirect effect, %b | 100 | NA |
Abbreviation: NA, not applicable.
a
Effect estimates are derived from linear regression models and are adjusted for baseline Alberta Stroke Program Early Computed Tomography Score, National Institutes of Health Stroke Scale, onset-to-puncture time, nerinetide treatment, and alteplase treatment.
b
Relative proportions of the indirect effect were calculated by dividing the absolute effect size of the indirect effect by the absolute effect size of the total effect of age on 90-day outcome. Because the proportion cannot exceed 100%, the composite frailty model is essentially 100%.