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Table 3.

Association between iodine status and thyroid volume and goiter-US.

Category UIC, μg/L n Thyroid volume (β, 95% CI) Goiter-US (OR, 95% CI)
Age-specific criteria BSA-specific criteria
Unadjusted Adjusteda Unadjusted Adjusteda Unadjusted Adjusteda
Adequate 100–299 48 0 (reference) 0 (reference) 1 (reference) 1 (reference) 1 (reference) 1 (reference)
Deficient <100 12 0.09 (−0.38, 0.54) 0.07 (−0.39, 0.52) 3.50 (0.81, 15.29) 3.40 (0.76, 15.18) 2.41 (0.64, 9.09) 2.12 (0.55, 8.13)
Mild excessive 300–499 35 0.02 (−0.31, 0.33) −0.01 (−0.33, 0.3) 2.08 (0.65, 6.65) 1.94 (0.59, 6.35) 1.35 (0.5, 3.65) 1.46 (0.53, 4.01)
Moderate excessive 500–999 49 0.12 (−0.17, 0.41) 0.16 (−0.12, 0.45) 2.80 (0.98, 8.06) 3.14 (1.07, 9.21)b 2.14 (0.88, 5.17) 2.35 (0.95, 5.81)
Severe excessive ≥ 1000 84 0.23 (−0.04, 0.49) 0.18 (−0.07, 0.44) 3.32 (1.26, 8.76)b 3.11 (1.16, 8.34)b 2.29 (1.03, 5.10)b 2.49 (1.09, 5.66)b

aAdjusted for age, sex, and body mass index Z-scores; bP < 0.05.

OR, odds ratio; UIC, urine iodine concentration; US, ultrasound..