Table I:
Demographic data of healthy term neonates and neonates with neonatal encephalopathy (NE)
| Control Cohort (n=30) | Total NE Cohort (n=155) | Trinity College Cohort (n=57) | Children’s National Cohort (n=98) | p-value | |
|---|---|---|---|---|---|
| Median (IQR) | |||||
| Gestational age (weeks) | 39.1 (37.9, 40.0) | 39.6 (38, 40.7) | 40.7 (40.0, 41.6) | 39.0 (38.0, 40.0) | 0.22a |
| Birthweight (kg) | 3.3 (3.1, 3.6) | 3.3 (2.9, 3.8) | 3.6 (3.2, 4.0) | 3.1 (2.8, 3.6) | 0.73a |
| First blood gas pH | 7.3 (7.2, 7.4) | 7.0 (6.9, 7.1) | 7.0 (6.9, 7.2) | 7.0 (6.8, 7.1) | <0.001a |
| 5-minute Apgar score | 10 (10, 10) | 4 (2, 6) | 5 (3, 7) | 3.5 (2, 5) | <0.001a |
| Sex, n (%) | |||||
| Male | 12 (40) | 88 (57) | 38 (68) | 50 (51) | 0.11b |
| Female | 18 (60) | 66 (43) | 18 (32) | 48 (49) | |
| Mode of Delivery, n (%) | |||||
| Cesarean | 9 (30) | 66 (52) | 20 (36) | 46 (64) | 0.04b |
| Vaginal | 21 (70) | 61 (48) | 35 (64) | 26 (36) | |
| Therapeutic Hypothermia, n (%) | |||||
| Yes | 0 (0) | 135 (88) | 37 (66) | 98 (100) | <0.001b |
| No | 30 (100) | 19 (12) | 19 (34) | 0 (0) | |
NE = neonatal encephalopathy.
a
Mann Whitney U test was used for comparison of the control cohort and the Total NE cohort.
b
Fisher’s exact test was used for comparison of control cohort and the Total NE cohort.