Table XII:

Association of plasma and CSF candidate biomarker concentrations of neonates with NE and Bayley Scales of Infant and Toddler Development III (Bayley-III) scores at 15–30 months^*

	Plasma						CSF
	Cognitive		Motor		Language		Cognitive		Motor		Language
	Coefficient (95% CI)	p	Coefficient (95% CI)	p	Coefficient (95% CI)	p	Coefficient (95% CI)	p	Coefficient (95% CI)	p	Coefficient (95% CI)	p
GFAP	−0.03 (−2.8–2.7)	0.98	−0.4 (−3.2–2.5)	0.80	0.3 (−2.8–3.3)	0.87	−9.2 (−17−-1.9)	0.02	−8.7 (−17−-0.5)	0.04	−7.0 (−15–1.1)	0.09
NRGN	−0.07 (−3.4–3.3)	0.97	−0.6 (−4.1–2.9)	0.73	0.2 (−3.5–3.9)	0.90	−22.4 (−34−-11.3)	0.001	−25.3 (−37−-13.8)	<0.001	−19.1 (−32−-6.0)	0.007
BDNF	1.4 (−2.3–5.2)	0.45	1.6 (−2.3–5.4)	0.43	0.9 (−3.3–5.0)	0.68	4.2 (−9.5–18.0)	0.52	5.0 (−9.8–19.6)	0.49	1.9 (−12.4–16.2)	0.78
IL-6	−2.2 (−5.2–0.8)	0.16	−2.2 (−5.3–0.9)	0.17	−2.5 (−5.8–0.8)	0.14	−4.4 (−8.0−-1.0)	0.02	−5.1 (−8.7- −1.5)	0.009	−3.6 (−7.5–0.3)	0.07
IL-8	−2.6 (−6.2–1.0)	0.16	−3.0 (−6.7–0.9)	0.13	−3.2 (−7.2–0.7)	0.11	−2.9 (−7.1–1.3)	0.16	−4.8 (−8.9- −0.6)	0.03	−2.5 (−7.0–1.9)	0.25
IL-10	−0.3 (−4.0–3.5)	0.89	−0.6 (−4.5–3.3)	0.76	−1.6 (−5.6–2.5)	0.45	−34.6 (−63−-5.9)	0.02	−42.0 (−71−-12.7)	0.008	−20.2 (−54–13.0)	0.22
VEGF	0.5 (−2.5–3.4)	0.75	0.9 (−2.2–3.9)	0.57	1.0 (−2.3–4.2)	0.56	−0.4 (−9.6–8.8)	0.93	0.08 (−9.8–10.0)	0.99	−1.5 (−11.0–8.1)	0.75
Tau	−5.6 (−10.6−-0.5)	0.03	−6.1 (−11.5−-0.7)	0.03	−5.4 (−10.9–0.2)	0.06	−2.1 (−6.8–2.7)	0.37	−2.6 (−7.5–2.3)	0.27	−0.8 (−5.8–4.1)	0.73

NE = neonatal encephalopathy.

^*Adjusted for gestational age and sex, the natural log of candidate biomarker concentrations were used in adjusted analyses. Plasma: Duplex (GFAP and NRGN): n=93; Multiplex (BDNF, IL-6, IL-8, IL-10, VEGF): n=92; Tau: n=81. CSF: Duplex (GFAP and NRGN): n=20; Multiplex (BDNF, IL-6, IL-8, IL-10, VEGF): n=20; Tau: n=17.