. Author manuscript; available in PMC: 2024 Jan 3.

Published in final edited form as: J Pediatr. 2020 Jun 28;226:71–79.e5. doi: 10.1016/j.jpeds.2020.06.078

Table III:

Comparison of plasma candidate biomarker concentrations in healthy term neonates and neonates with NE

	Control Cohort Median (IQR)	NE Cohort Median (IQR)	p
GFAP	80 (31, 553)	221 (9.0, 1008)	0.75
NRGN	8 (8, 8)	34 (7, 374)	0.03
BDNF	1376.9 (867.8, 2629.0)	407.3 (152.5, 1161.0)	<0.001
IL-6	4.9 (2.6, 14.3)	28.4 (9.8, 119.9)	<0.001
IL-8	32.2 (24.4, 47.0)	113.5 (52.3, 394.9)	<0.001
IL-10	0.7 (0.3, 2.2)	8.5 (2.2, 48.8)	<0.001
VEGF	276.1 (142.3, 319.9)	12.9 (0.9, 60.7)	<0.001
Tau	111.4 (32.8, 182.3)	243.1 (115.1, 541.0)	<0.001

NE = neonatal encephalopathy. All analyses used the Mann-Whitney U test for comparisons of non-parametric data. Candidate biomarker units are pg/mL. Duplex (GFAP and NRGN): Control n=24, NE n=141; Multiplex (BDNF, IL-6, IL-8, IL-10, VEGF): Control n=29, NE n=141; Tau: Control n=27, NE n=123