. Author manuscript; available in PMC: 2024 Jan 3.

Published in final edited form as: J Pediatr. 2020 Jun 28;226:71–79.e5. doi: 10.1016/j.jpeds.2020.06.078

Table VII:

Univariate Analysis of plasma candidate biomarker concentrations of neonates with NE and seizure occurrence

	No Median (IQR)	Yes Median (IQR)	p
GFAP	224 (9, 878)	153 (9, 1008)	0.96
NRGN	57 (7, 549)	17 (7, 313)	0.64
BDNF	373.2 (149.6, 1112.5)	480.5 (183.2, 1525.5)	0.52
IL-6	43.7 (13.4, 295.5)	22.7 (6.5, 66.8)	0.02
IL-8	100.8 (53.6, 341.6)	130.7 (47.5, 439.3)	0.75
IL-10	11.4 (2.9, 36.4)	7.6 (1.3, 59.5)	0.39
VEGF	10.0 (0.2, 76.5)	14.3 (0.9, 52.6)	0.79
Tau	251.9 (123.8, 528.2)	239.8 (119.2, 554.5)	0.90

NE = neonatal encephalopathy. Univariate analyses used the Mann-Whitney U test for comparisons of non-parametric data. Candidate biomarker units are pg/mL. Duplex (GFAP and NRGN): No n=58, Yes n=67; Multiplex (BDNF, IL-6, IL-8, IL-10, VEGF): No n=60, Yes n=65; Tau: No n=51, Yes n=58.