Table 3.

Current database for eccDNA.

Database	Website	Number of eccDNA	Species	Function	References
CircleBase	http://circlebase.maolab.org	601,036	Homo sapiens	Scores eccDNAs and helps to interpret the potential functions of eccDNA in the human genome using a powerful system, combined with six annotation sections, including “targeting genes”, “epigenetic regulations”, “regulatory elements”, “chromatin accessibility”, “chromatin interactions”, and “genetic variants”	Zhao et al. (2022)
eccDNAdb	http://www.eccdnadb.org	1,270	Homo sapiens	Acquires known and novel eccDNAs in cancers by computational analysis of WGS data, and annotates and illustrates their potential role in human cancer	Peng et al. (2022)
eccDNA Atlas	http://lcbb.swjtu.edu.cn/eccDNAatlas	639,313	Homo sapiens, Arabidopsis thaliana, Drosophila Mus musculus, Cricetulus griseus, Yeast, Gallus gallus	Provides a high-quality and integrated resource for browsing, searching and analyzing eccDNAs, such as sequence, function/characteristic, validation strategies from multiple species	Zhong et al. (2023)