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. 2024 Jan 3;14(2):1304–1315. doi: 10.1039/d3ra06993a

Anti-cancer activity screening results.

Compounds Cell viability (%) ±SD
MCF-7 MDA-MB-453 MCF-10A
25 μM 10 μM 1 μM 25 μM 10 μM 1 μM 25 μM 50 μM 100 μM
23 31.7 ± 4.0 40.3 ± 3.6 66.7 ± 1.18 77.1 ± 5.7 88.4 ± 5.4 80.6 ± 8.0 88.6 ± 1.5 86.3 ± 2.9 84.2 ± 3.0
26 52.8 ± 3.0 65.8 ± 1.8 80.0 ± 4.5 66.3 ± 5.8 84.2 ± 11.5 87.8 ± 3.2 87.8 ± 2.8 85.6 ± 0.7 82.0 ± 1.5
30 42.3 ± 7.6 57.7 ± 2.4 78.2 ± 2.6 61.4 ± 3.2 74.8 ± 1.5 99.2 ± 8.1 86.8 ± 5.3 84.8 ± 3.0 78.5 ± 3.4
33 25.0 ± 2.9 35.0 ± 2.5 67.0 ± 4.7 67.6 ± 5.3 78.3 ± 4.7 88.8 ± 5.2 99.6 ± 2.2 87.6 ± 1.7 81.4 ± 2.6
36 28.1 ± 4.4 32.4 ± 0.9 52.3 ± 3.1 63.8 ± 1.7 82.9 ± 1.2 91.5 ± 4.6 88.6 ± 1.5 86.1 ± 2.8 84.2 ± 3.0
41 48.1 ± 3.5 58.2 ± 3.8 72.8 ± 4.2 95.1 ± 35.7 77.4 ± 5.4 96.4 ± 4.8 89.8 ± 2.8 84.2 ± 5.8 83.0 ± 1.5
YM155 (20 nM) 31.2 ± 1.7 31.2 ± 1.7 31.2 ± 1.7 36.2 ± 1.5 36.2 ± 1.5 36.2 ± 1.5 39.2 ± 1.6 39.2 ± 1.6 39.2 ± 1.6