Anti-cancer activity screening results.
| Compounds | Cell viability (%) ±SD | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| MCF-7 | MDA-MB-453 | MCF-10A | |||||||
| 25 μM | 10 μM | 1 μM | 25 μM | 10 μM | 1 μM | 25 μM | 50 μM | 100 μM | |
| 23 | 31.7 ± 4.0 | 40.3 ± 3.6 | 66.7 ± 1.18 | 77.1 ± 5.7 | 88.4 ± 5.4 | 80.6 ± 8.0 | 88.6 ± 1.5 | 86.3 ± 2.9 | 84.2 ± 3.0 |
| 26 | 52.8 ± 3.0 | 65.8 ± 1.8 | 80.0 ± 4.5 | 66.3 ± 5.8 | 84.2 ± 11.5 | 87.8 ± 3.2 | 87.8 ± 2.8 | 85.6 ± 0.7 | 82.0 ± 1.5 |
| 30 | 42.3 ± 7.6 | 57.7 ± 2.4 | 78.2 ± 2.6 | 61.4 ± 3.2 | 74.8 ± 1.5 | 99.2 ± 8.1 | 86.8 ± 5.3 | 84.8 ± 3.0 | 78.5 ± 3.4 |
| 33 | 25.0 ± 2.9 | 35.0 ± 2.5 | 67.0 ± 4.7 | 67.6 ± 5.3 | 78.3 ± 4.7 | 88.8 ± 5.2 | 99.6 ± 2.2 | 87.6 ± 1.7 | 81.4 ± 2.6 |
| 36 | 28.1 ± 4.4 | 32.4 ± 0.9 | 52.3 ± 3.1 | 63.8 ± 1.7 | 82.9 ± 1.2 | 91.5 ± 4.6 | 88.6 ± 1.5 | 86.1 ± 2.8 | 84.2 ± 3.0 |
| 41 | 48.1 ± 3.5 | 58.2 ± 3.8 | 72.8 ± 4.2 | 95.1 ± 35.7 | 77.4 ± 5.4 | 96.4 ± 4.8 | 89.8 ± 2.8 | 84.2 ± 5.8 | 83.0 ± 1.5 |
| YM155 (20 nM) | 31.2 ± 1.7 | 31.2 ± 1.7 | 31.2 ± 1.7 | 36.2 ± 1.5 | 36.2 ± 1.5 | 36.2 ± 1.5 | 39.2 ± 1.6 | 39.2 ± 1.6 | 39.2 ± 1.6 |